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INDICATION AND IMPORTANT SAFETY INFORMATION

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For acne vulgaris, the ONLY WAY to TOPICALLY

TARGET ANDROGEN RECEPTORS1,2*

FEMALE & MALE

12+

WINLEVI (clascoterone) cream 1% is an androgen receptor inhibitor indicated for the topical treatment of acne vulgaris in patients 12 years of age and older.
Hypothetical WINLEVI® (clascoterone cream 1%) Patients

Not actual patients.

*The exact mechanism of WINLEVI in acne vulgaris is unknown.1

#1 ACNE TOPICAL BRAND PRESCRIBED BY DERMATOLOGISTS3

FDA-approved WINLEVI is the FIRST novel topical mechanism for acne in 40 years2,4,5*

WINLEVI (clascoterone) cream 1% is an androgen receptor inhibitor appropriate for use in both FEMALE and MALE acne patients.1,4

Hypothetical Female WINLEVI® (clascoterone cream 1%) Patient

Not actual patient.

Hypothetical Male WINLEVI® (clascoterone cream 1%) Patient

Not actual patient.

Inhibits effects

of androgen hormones on cells in sebaceous glands1,4,6

Treatment success

increases over time7,8‡

Significantly reduces

inflammatory and noninflammatory lesions1,4

No systemic side effects

related to androgen inhibition

7% to 12%

of patients experienced erythema/reddening, pruritus and scaling/dryness1,4†

Appropriate for

FEMALE and MALE patients aged 12 and up1,4

*The exact mechanism of WINLEVI in acne vulgaris is unknown.1
Additionally, edema, stinging, and burning occurred in >3% of patients and were reported in a similar percentage of subjects treated with vehicle.
Phase 3, long-term, open-label, 9-month safety extension study was not designed to assess efficacy; long-term efficacy was not a primary endpoint.
§In a maximum-use PK study in 42 patients, hypothalamic-pituitary-adrenal (HPA) axis suppression was observed in 5% (1/20) of adults (6 g BID) and 9% (2/22) of adolescents (4 g BID) at Day 14. All patients returned to normal HPA axis function at follow-up 4 weeks after the end of treatment.8 Attempt to withdraw use if HPA axis suppression develops.1

ALL ACNE HAS A HORMONAL COMPONENT

You may have talked about hormonal acne with some of your patients, especially your female patients. But the androgen hormone (dihydrotestosterone or DHT) is a key driver in acne vulgaris in both FEMALES and MALES, as receptor-bound androgens stimulate sebaceous gland activity and sebum production.10,11

DHT Androgen Hormone

Not actual patients.