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INDICATION AND IMPORTANT SAFETY INFORMATION

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HOW IT
WORKS

THE
WINLEVI ®
WAY
Hypothetical Male and Female WINLEVI® (clascoterone cream 1%) Patients
A UNIQUE WAY TO TOPICALLY TREAT ACNE •

FIRST & ONLY TOPICAL MECHANISM

TO INHIBIT ANDROGEN RECEPTORS IN ACNE VULGARIS1-4*

Androgens such as testosterone and dihydrotestosterone (DHT) play a key role in acne in both sexes. Androgens bind to androgen receptors in the sebaceous gland, causing sebum production and inflammation.4-6
Androgen Binding to Androgen Receptor
Comparison of DHT in Sebaceous Gland in Skin Without Acne Versus Skin With Acne

WINLEVI MECHANISM OF ACTION*

Within the skin, WINLEVI binds to androgen receptors, competing with the binding of androgens such as DHT.1,3,4

Studies suggest this inhibits the action of androgen receptors on cells in the sebaceous gland, reducing sebum production and inflammation.1,3,4

*However, the exact mechanism of WINLEVI in acne vulgaris is unknown.1

WINLEVI® (clascoterone) cream 1% Binding to Androgen Receptors

WINLEVI TARGETS THE ANDROGEN COMPONENT OF ACNE IN FEMALES AND MALES1,3,4

Hypothetical WINLEVI® (clascoterone) cream 1% Male and Female Patients
WINLEVI® (clascoterone) cream 1% Prescription Tube

Androgens play a key role in both FEMALE and MALE acne vulgaris patients

EXPLORE THE ROLE OF ANDROGENS
JAMADermatology

Read more about how WINLEVI targets androgen receptors in acne